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Identification of self through two-dimensional chemistry and synapses.

Abstract:

Cells in the immune and nervous systems communicate through informational synapses. The two-dimensional chemistry underlying the process of synapse formation is beginning to be explored using fluorescence imaging and mechanical techniques. Early analysis of two-dimensional kinetic rates (k(on) and k(off)) and equilibrium constants (K(d)) provides a number of biological insights. First, there are two regimes for adhesion-one disordered with slow k(on) and the other self-ordered with 10(4)-fold...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Annual review of cell and developmental biology
Volume:
17
Pages:
133-157
Publication date:
2001-01-01
DOI:
EISSN:
1530-8995
ISSN:
1081-0706
URN:
uuid:2b4b4406-07de-42e3-b2d2-4db7780af1a8
Source identifiers:
482659
Local pid:
pubs:482659

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