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Characterization of intercellular adhesion molecule-1 ectodomain (sICAM-1) as an inhibitor of lymphocyte function-associated molecule-1 interaction with ICAM-1.

Abstract:

Intercellular adhesion molecule-1 (ICAM-1) is a member of the Ig superfamily, contains five Ig-like domains comprising the extracellular portion of the molecule, and interacts with lymphocyte function-associated molecule-1 (LFA-1), a member of the beta 2-integrin family. LFA-1/ICAM-1 interaction is important in a variety of cellular events including Ag-specific T cell activation and leukocyte transendothelial migration. Recently, a soluble circulating form of ICAM-1 has been detected in human...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Carron, CP More by this author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
155
Issue:
7
Pages:
3578-3584
Publication date:
1995-10-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:2b3ba260-f78f-42ff-bf51-91e39597bb42
Source identifiers:
482685
Local pid:
pubs:482685

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