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Effect of the latent reservoir on the evolution of HIV at the within- and between- host levels

Abstract:

The existence of long-lived reservoirs of latently infected CD4+ T cells is the major barrier to curing HIV, and has been extensively studied in this light. However, the effect of these reservoirs on the evolutionary dynamics of the virus has received little attention. Here, we present a within-host quasispecies model that incorporates a long-lived reservoir, which we then nest into an epidemiological model of HIV dynamics. For biologically plausible parameter values, we find that the presenc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1005228

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Computational Biology Journal website
Volume:
13
Issue:
1
Article number:
e1005228
Publication date:
2017-01-01
Acceptance date:
2016-11-23
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Pubs id:
pubs:671144
UUID:
uuid:2b316c77-c7c1-4061-9ea9-a82b041a9a12
Local pid:
pubs:671144
Deposit date:
2017-01-16

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