Journal article
Effect of the latent reservoir on the evolution of HIV at the within- and between- host levels
- Abstract:
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The existence of long-lived reservoirs of latently infected CD4+ T cells is the major barrier to curing HIV, and has been extensively studied in this light. However, the effect of these reservoirs on the evolutionary dynamics of the virus has received little attention. Here, we present a within-host quasispecies model that incorporates a long-lived reservoir, which we then nest into an epidemiological model of HIV dynamics. For biologically plausible parameter values, we find that the presenc...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.3MB)
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- Publisher copy:
- 10.1371/journal.pcbi.1005228
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Computational Biology Journal website
- Volume:
- 13
- Issue:
- 1
- Article number:
- e1005228
- Publication date:
- 2017-01-01
- Acceptance date:
- 2016-11-23
- DOI:
- EISSN:
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1553-7358
- ISSN:
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1553-734X
Item Description
- Pubs id:
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pubs:671144
- UUID:
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uuid:2b316c77-c7c1-4061-9ea9-a82b041a9a12
- Local pid:
- pubs:671144
- Deposit date:
- 2017-01-16
Terms of use
- Copyright holder:
- Doekes et al
- Copyright date:
- 2017
- Notes:
- Copyright: © 2017 Doekes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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