- Abstract:
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The existence of long-lived reservoirs of latently infected CD4+ T cells is the major barrier to curing HIV, and has been extensively studied in this light. However, the effect of these reservoirs on the evolutionary dynamics of the virus has received little attention. Here, we present a within-host quasispecies model that incorporates a long-lived reservoir, which we then nest into an epidemiological model of HIV dynamics. For biologically plausible parameter values, we find that the presenc...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.3MB)
-
- Publisher copy:
- 10.1371/journal.pcbi.1005228
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Computational Biology Journal website
- Volume:
- 13
- Issue:
- 1
- Pages:
- Article: e1005228
- Publication date:
- 2017-01-01
- Acceptance date:
- 2016-11-23
- DOI:
- EISSN:
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1553-7358
- ISSN:
-
1553-734X
- Pubs id:
-
pubs:671144
- URN:
-
uri:2b316c77-c7c1-4061-9ea9-a82b041a9a12
- UUID:
-
uuid:2b316c77-c7c1-4061-9ea9-a82b041a9a12
- Local pid:
- pubs:671144
- Paper number:
- 1
- Copyright holder:
- Doekes et al.
- Copyright date:
- 2017
- Notes:
- Copyright: © 2017 Doekes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Effect of the latent reservoir on the evolution of HIV at the within- and between- host levels
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