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Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease

Abstract:

Adhesion between the opacity-associated adhesin (Opa) proteins of Neisseria meningitidis and human carcino-embryonic antigen cell adhesion molecule (CEACAM) proteins is an important stage in the pathogenesis of meningococcal disease, a globally important bacterial infection. Most disease is caused by a small number of meningococcal genotypes known as hyperinvasive lineages. As these are also carried asymptomatically, acquisition of them alone cannot explain why only some hosts develop meningo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/sj.gene.6364442

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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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Author
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
Role:
Author
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Institution:
"Institute of Child Health, London, UK"
Department:
Department of Clinical Molecular Genetics
Role:
Author
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Institution:
"Imperial College London"
Department:
Department of Paediatrics,Faculty of Medicine,Wright Fleming Institute
Role:
Author
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Funding agency for:
D. P. Kwiatkowski
Meningitis Research Foundation More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Genes and Immunity Journal website
Volume:
9
Issue:
1
Pages:
30-37
Publication date:
2008-01-05
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
URN:
uuid:2b2bd3d7-4464-4340-b3cd-2d3909c858dd
Local pid:
ora:3191

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