Wnt signaling and Dupuytren's disease.

Journal article

BACKGROUND: Dupuytren's disease is a benign fibromatosis of the hands and fingers that leads to flexion contractures. We hypothesized that multiple genetic and environmental factors influence susceptibility to this disease and sought to identify susceptibility genes to better understand its pathogenesis. METHODS: We conducted a genomewide association study of 960 Dutch persons with Dupuytren's disease and 3117 controls (the discovery set) to test for association between the disease and genet...

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Authors: Dolmans, G; Werker, P; Hennies, H; Furniss, D; Festen, E

• Publication status: Published
• Journal: New England journal of medicine
• Volume: 365
• Issue: 4
• Pages: 307-317
• Publication date: 2011-07-01
• DOI: 10.1056/nejmoa1101029
• EISSN: 1533-4406
• ISSN: 0028-4793
• Language: English
• Keywords: German Dupuytren Study Group; Genetic Loci; Wnt Proteins; Genome-Wide Association Study; BSSH-GODD Consortium; Signal Transduction; Humans; Europe; Polymorphism, Single Nucleotide; Genetic Predisposition to Disease; Dupuytren Contracture; LifeLines Cohort Study; Case-Control Studies; Dutch Dupuytren Study Group