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Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.

Abstract:

Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the es...

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Publisher copy:
10.1084/jem.20050783

Authors


Tadokoro, CE More by this author
Shakhar, G More by this author
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Journal:
The Journal of experimental medicine
Volume:
203
Issue:
3
Pages:
505-511
Publication date:
2006-03-13
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:2b026472-7484-41e2-a946-947e92a88b4f
Source identifiers:
482614
Local pid:
pubs:482614

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