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A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States.

Abstract:

Several quantitative trait loci (QTLs) that influence developmental dyslexia (reading disability [RD]) have been mapped to chromosome regions by linkage analysis. The most consistently replicated area of linkage is on chromosome 6p23-21.3. We used association analysis in 223 siblings from the United Kingdom to identify an underlying QTL on 6p22.2. Our association study implicates a 77-kb region spanning the gene TTRAP and the first four exons of the neighboring uncharacterized gene KIAA0319. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1086/426404

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Wellcome Trust More from this funder
Publisher:
Cell Press Publisher's website
Journal:
American journal of human genetics Journal website
Volume:
75
Issue:
6
Pages:
1046-1058
Publication date:
2004-12-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:2af2ea6f-3c8e-4692-bc8b-7b277f1adf00
Source identifiers:
32890
Local pid:
pubs:32890

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