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Intensity-modulated radiotherapy allows escalation of the radiation dose to the pelvic lymph nodes in patients with locally advanced prostate cancer: preliminary results of a phase I dose escalation study.

Abstract:

AIM: Pelvic irradiation in addition to prostate irradiation may improve outcome in locally advanced prostate cancer, but is associated with dose-limiting bowel toxicity. We report the preliminary results of a dose escalation study using intensity-modulated radiotherapy. MATERIALS AND METHODS: Eligible patients had high-risk (T3, Gleason > or =8 or prostate-specific antigen > or =20 ng/ml) or lymph node-positive disease. Intensity-modulated radiotherapy was inverse planned giving 70 Gy/3...

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Publication status:
Published

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Publisher copy:
10.1016/j.clon.2010.01.005

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Clinical oncology (Royal College of Radiologists (Great Britain))
Volume:
22
Issue:
3
Pages:
236-244
Publication date:
2010-04-05
DOI:
EISSN:
1433-2981
ISSN:
0936-6555
URN:
uuid:2af0365c-f093-4f48-ac78-8dd365a81e19
Source identifiers:
55537
Local pid:
pubs:55537

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