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Thesis

Transcriptional mechanisms influencing glycaemic traits and risk of type 2 diabetes

Abstract:

Genome-wide association studies (GWASs) have identifified many genetic variants associated with type 2 diabetes (T2D) risk and glycaemic traits, most of which are noncoding. Although existing islet RNA sequencing (RNA-seq) studies have identified genes regulated by T2D-associated variants, sample sizes are small, and most known regulatory targets are messenger RNAs RNAs). The work presented in this thesis aims to characterise long noncoding RNA (lncRNA) expression in islets, identify can...

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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