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Measuring the neuromodulatory effects of drugs in man with positron emission tomography.

Abstract:

Cognitive activation in conjunction with pharmacological challenge was used to demonstrate neuromodulation in man. Using positron emission tomography (PET), measurements of regional cerebral blood flow were made during the performance of memory tasks, before and after the administration of apomorphine (dopamine agonist), buspirone (5-HT1A partial agonist) or placebo. Drug effects on memory-induced increases in regional cerebral blood flow were assessed, on a voxel-by-voxel basis, using statis...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Neuroscience letters
Volume:
141
Issue:
1
Pages:
106-110
Publication date:
1992-07-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:2ae0e3b2-2181-4de5-b286-551f4cad26a5
Source identifiers:
186035
Local pid:
pubs:186035

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