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Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions.

Abstract:

Cell-penetrating peptides (CPPs) are short cationic peptides that have been extensively studied as drug delivery vehicles for proteins, nucleic acids and nanoparticles. However, the formulation of CPP-based therapeutics into different pharmaceutical formulations and their stability in relevant biological environments have not been given the same attention. Here, we show that a newly developed CPP, PepFect 14 (PF14), forms non-covalent nanocomplexes with short interfering RNA (siRNA), which ar...

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Journal:
Journal of controlled release : official journal of the Controlled Release Society
Volume:
162
Issue:
1
Pages:
1-8
Publication date:
2012-08-05
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
URN:
uuid:2ade086b-dc53-4a43-aa76-bc3d3621e071
Source identifiers:
340060
Local pid:
pubs:340060

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