Journal article icon

Journal article

Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia.

Abstract:

Macrophage activation is essential for protection against bacterial pathogens but needs to be regulated to prevent damage to the host. We show a key role for the immune inhibitory receptor CD200R and its ligand CD200 in the context of infection with the Gram-negative human pathogen Neisseria meningitidis. N. meningitidis induced CD200 but downregulated CD200R on macrophages in a manner dependent on Neisserial lipopolysaccharide, Toll-like receptor-4 (TLR-4), and the MyD88 pathway but independ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.chom.2010.08.005

Authors


Journal:
Cell host and microbe
Volume:
8
Issue:
3
Pages:
236-247
Publication date:
2010-09-01
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
Source identifiers:
73301

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP