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Journal article

Innate immunity and monocyte-macrophage activation in atherosclerosis.

Abstract:

Innate inflammation is a hallmark of both experimental and human atherosclerosis. The predominant innate immune cell in the atherosclerotic plaque is the monocyte-macrophage. The behaviour of this cell type within the plaque is heterogeneous and depends on the recruitment of diverse monocyte subsets. Furthermore, the plaque microenvironment offers polarisation and activation signals which impact on phenotype. Microenvironmental signals are sensed through pattern recognition receptors, includ...

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Publication status:
Published

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Publisher copy:
10.1186/1476-9255-8-9

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, BHF Centre of Research Excellence
Role:
Author
Journal:
Journal of inflammation (London, England)
Volume:
8
Issue:
1
Pages:
9
Publication date:
2011-01-01
DOI:
EISSN:
1476-9255
ISSN:
1476-9255
URN:
uuid:2ac58c3d-5837-4123-b12a-6ef8b83d80bd
Source identifiers:
226959
Local pid:
pubs:226959

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