Journal article
Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.
- Abstract:
-
Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. However, little is known about the genome-wide frequency, localization, and function of methylation variation and how it is regulated by genetic and environmental factors. We utilized the Multiple Tissue Human Expression Resource (MuTHER) and generated Illumina 450K adipose methylome data from 648 twins. We found that individual CpGs had low variance and that variability was suppres...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.ajhg.2013.10.004
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Authors
Bibliographic Details
- Journal:
- American journal of human genetics
- Volume:
- 93
- Issue:
- 5
- Pages:
- 876-890
- Publication date:
- 2013-11-01
- DOI:
- EISSN:
-
1537-6605
- ISSN:
-
0002-9297
- Source identifiers:
-
439525
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:439525
- UUID:
-
uuid:2aa21db0-4f9c-422a-9cab-f4c1916e440a
- Local pid:
- pubs:439525
- Deposit date:
- 2014-05-12
Terms of use
- Copyright date:
- 2013
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