Journal article icon

Journal article

Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.

Abstract:

Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. However, little is known about the genome-wide frequency, localization, and function of methylation variation and how it is regulated by genetic and environmental factors. We utilized the Multiple Tissue Human Expression Resource (MuTHER) and generated Illumina 450K adipose methylome data from 648 twins. We found that individual CpGs had low variance and that variability was suppres...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.ajhg.2013.10.004

Authors


Expand authors...
Journal:
American journal of human genetics
Volume:
93
Issue:
5
Pages:
876-890
Publication date:
2013-11-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:2aa21db0-4f9c-422a-9cab-f4c1916e440a
Source identifiers:
439525
Local pid:
pubs:439525

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP