- Abstract:
-
Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. However, little is known about the genome-wide frequency, localization, and function of methylation variation and how it is regulated by genetic and environmental factors. We utilized the Multiple Tissue Human Expression Resource (MuTHER) and generated Illumina 450K adipose methylome data from 648 twins. We found that individual CpGs had low variance and that variability was suppres...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.ajhg.2013.10.004
-
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- Journal:
- American journal of human genetics
- Volume:
- 93
- Issue:
- 5
- Pages:
- 876-890
- Publication date:
- 2013-11-05
- DOI:
- EISSN:
-
1537-6605
- ISSN:
-
0002-9297
- URN:
-
uuid:2aa21db0-4f9c-422a-9cab-f4c1916e440a
- Source identifiers:
-
439525
- Local pid:
- pubs:439525
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.
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