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The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder.

Abstract:

The KE family is a large three-generation pedigree in which half the members are affected with a severe speech and language disorder that is transmitted as an autosomal dominant monogenic trait. In previously published work, we localized the gene responsible (SPCH1) to a 5.6-cM region of 7q31 between D7S2459 and D7S643. In the present study, we have employed bioinformatic analyses to assemble a detailed BAC-/PAC-based sequence map of this interval, containing 152 sequence tagged sites (STSs),...

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Publication status:
Published

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Publisher copy:
10.1086/303011

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Hodgson, S More by this author
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Journal:
American journal of human genetics
Volume:
67
Issue:
2
Pages:
357-368
Publication date:
2000-08-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:2a868b26-1e56-4310-8583-4ba5ce96eeb0
Source identifiers:
31714
Local pid:
pubs:31714

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