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Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage.

Abstract:

The relative contribution of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)4 and ADAMTS5 to aggrecan degradation under oncostatin M (OSM) stimulation, the role of the ancillary domains of the aggrecanases on their ability to cleave within the chondroitin sulfate (CS)-2 region, the role of hyaluronidases (HYAL) in stimulating aggrecan release in the absence of proteolysis, and the identity of the hyaluronidase involved in OSM-mediated cartilage breakdown were investiga...

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Publication status:
Published

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Authors


Durigova, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Roughley, PJ More by this author
Journal:
European cells and materials
Volume:
21
Pages:
31-45
Publication date:
2011
EISSN:
1473-2262
ISSN:
1473-2262
URN:
uuid:2a826c35-5029-45e7-9606-5bc75d376b24
Source identifiers:
227103
Local pid:
pubs:227103

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