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Post-conditioning with lipopolysaccharide reduces the inflammatory infiltrate to the injured brain and spinal cord: a potential neuroprotective treatment.

Abstract:

Systemic infection often accompanies or precedes acute brain injury, but it remains unclear how the systemic response contributes to outcome. To examine this problem we have microinjected recombinant interleukin-1beta (IL-1beta), a cytokine associated with acute brain injury, into the rat brain parenchyma and either preceded or followed this challenge with the intravenous injection of lipopolysaccharide (LPS), which mimics systemic inflammatory response syndrome. The microinjection of IL-1bet...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
The European journal of neuroscience
Volume:
22
Issue:
10
Pages:
2441-2450
Publication date:
2005-11-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:2a7cdaa7-1319-4641-9814-fc041eb4f078
Source identifiers:
185226
Local pid:
pubs:185226

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