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Journal article

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

Abstract:

Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the immune system by activating inflammatory caspases and cytokines such as IL-1β. The nature of endogenous stress signals that activate inflammasomes remains unclear. Here we show that an inhibitor of the HIV aspartyl protease, Nelfinavir, triggers inflammasome formation and elicits an IL-1R-dependent inflammation in mice. We found that Nelfinavir impaired the maturation of lamin A, a structural component...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1602419113

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Name:
European Research Council
Grant:
Starting Grant 281996
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences More from this journal
Volume:
113
Issue:
32
Pages:
E4671-E4680
Publication date:
2016-08-09
Acceptance date:
2016-06-21
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:686553
UUID:
uuid:2a7a2b5b-e1ae-43b2-831c-a8a9f3ff84d6
Local pid:
pubs:686553
Source identifiers:
686553
Deposit date:
2017-07-14

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