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Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase.

Abstract:

BACKGROUND: The regulation of milk lactose biosynthesis is highly dependent on the action of a specifier protein, alpha-lactalbumin (LA). Together with a glycosyltransferase, LA forms the enzyme complex lactose synthase. LA promotes the binding of glucose to the complex and facilitates the biosynthesis of lactose. To gain further insight into the molecular basis of LA function in lactose synthase we have determined the structures of three species variants of LA. RESULTS: The crystal structure...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
Journal:
Structure (London, England : 1993)
Volume:
4
Issue:
6
Pages:
691-703
Publication date:
1996-06-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:2a760330-ba70-4062-9714-c5b61df9768e
Source identifiers:
317566
Local pid:
pubs:317566

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