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Bretylium abolishes neurotransmitter release without necessarily abolishing the nerve terminal action potential in sympathetic terminals

Abstract:

Background and purpose: The antidysrhythmic bretylium is useful experimentally because it selectively abolishes neurotransmitter release from sympathetic peripheral nerve terminals. Its mechanism of action seemed settled, but recent results from optical monitoring of single terminals now suggests a new interpretation.

Experimental approach: Orthograde transport of a dextran-conjugated Ca2+ indicator to monitor Ca2+ in nerve ter...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/sj.bjp.0707623

Authors


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Institution:
University of Oxford
Oxford college:
Christ Church
Department:
Medical Sciences Division - Pharmacology
More by this author
Institution:
University of Oxford
Oxford college:
Hertford College
Department:
Medical Sciences Division - Pharmacology
More from this funder
Funding agency for:
Keith L. Brain
Publisher:
Wiley-Blackwell
Journal:
British Journal of Pharmacology Journal website
Volume:
153
Issue:
4
Pages:
831–839
Publication date:
2008
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:2a716ca3-6aa5-4292-8e53-b4422925bba9
Local pid:
ora:7894

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