Bretylium abolishes neurotransmitter release without necessarily abolishing the nerve terminal action potential in sympathetic terminals
Background and purpose: The antidysrhythmic bretylium is useful experimentally because it selectively abolishes neurotransmitter release from sympathetic peripheral nerve terminals. Its mechanism of action seemed settled, but recent results from optical monitoring of single terminals now suggests a new interpretation.
Experimental approach: Orthograde transport of a dextran-conjugated Ca2+ indicator to monitor Ca2+ in nerve ter...Expand abstract
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