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Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses.

Abstract:

Protection against liver-stage malaria relies on the induction of high frequencies of antigen-specific CD8+ T cells. We have previously reported high protective levels against mouse malaria, albeit short-lived, by a single vaccination with adenoviral vectors coding for a liver-stage antigen (ME.TRAP). Here, we report that prime-boost regimens using modified vaccinia virus Ankara (MVA) and adenoviral vectors encoding ME.TRAP can enhance both short- and long-term sterile protection against mala...

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Publication status:
Published

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Publisher copy:
10.1128/iai.00740-09

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Berthoud, T More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Journal:
Infection and immunity
Volume:
78
Issue:
1
Pages:
145-153
Publication date:
2010-01-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:2a6e6049-9817-4252-89ff-3166aa775a92
Source identifiers:
34950
Local pid:
pubs:34950

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