- Abstract:
-
Protection against liver-stage malaria relies on the induction of high frequencies of antigen-specific CD8+ T cells. We have previously reported high protective levels against mouse malaria, albeit short-lived, by a single vaccination with adenoviral vectors coding for a liver-stage antigen (ME.TRAP). Here, we report that prime-boost regimens using modified vaccinia virus Ankara (MVA) and adenoviral vectors encoding ME.TRAP can enhance both short- and long-term sterile protection against mala...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/iai.00740-09
-
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- Journal:
- Infection and immunity
- Volume:
- 78
- Issue:
- 1
- Pages:
- 145-153
- Publication date:
- 2010-01-05
- DOI:
- EISSN:
-
1098-5522
- ISSN:
-
0019-9567
- URN:
-
uuid:2a6e6049-9817-4252-89ff-3166aa775a92
- Source identifiers:
-
34950
- Local pid:
- pubs:34950
- Copyright date:
- 2010
Journal article
Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses.
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