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Journal article

Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts

Abstract:

Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β2-adrenoceptor (β2AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy. However, both cell types produce comparable cytosolic amounts of the second messenger cAMP. We investigated this discrepancy using nanoscale imaging techniques and found that, structurally, basal cardiomyocytes have more organized membranes (higher T-tubular and caveolar densities). Local memb...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2018.03.053

Authors


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Gertraud und Heinz Rose Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
23
Issue:
2
Pages:
459-469
Publication date:
2018-04-10
Acceptance date:
2018-03-13
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:835542
URN:
uri:2a639c4c-bc05-464e-a938-f1d220c7c17c
UUID:
uuid:2a639c4c-bc05-464e-a938-f1d220c7c17c
Local pid:
pubs:835542

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