- Abstract:
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Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β2-adrenoceptor (β2AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy. However, both cell types produce comparable cytosolic amounts of the second messenger cAMP. We investigated this discrepancy using nanoscale imaging techniques and found that, structurally, basal cardiomyocytes have more organized membranes (higher T-tubular and caveolar densities). Local memb...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.4MB)
-
- Publisher copy:
- 10.1016/j.celrep.2018.03.053
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 23
- Issue:
- 2
- Pages:
- 459-469
- Publication date:
- 2018-04-10
- Acceptance date:
- 2018-03-13
- DOI:
- EISSN:
-
2211-1247
- ISSN:
-
2211-1247
- Pubs id:
-
pubs:835542
- URN:
-
uri:2a639c4c-bc05-464e-a938-f1d220c7c17c
- UUID:
-
uuid:2a639c4c-bc05-464e-a938-f1d220c7c17c
- Local pid:
- pubs:835542
- Language:
- English
- Keywords:
- Copyright holder:
- Zaccolo et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Journal article
Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts
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Gertraud und Heinz Rose Foundation
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