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Refining the roles of GABAergic signaling during neural circuit formation.

Abstract:

Our understanding of the role of GABA signaling in circuit development is rapidly expanding. Here, we review three recent refinements in our understanding of the diverse roles that GABA plays at different stages of neural circuit formation. First, we discuss recent evidence that depolarizing GABA plays at least a permissive role in promoting both excitatory and inhibitory synaptogenesis in developing neurons (including newly generated neurons in the adult). Next, we discuss recent evidence th...

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Publication status:
Published

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Publisher copy:
10.1016/j.tins.2007.06.002

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Trends in neurosciences
Volume:
30
Issue:
8
Pages:
382-389
Publication date:
2007-08-05
DOI:
EISSN:
1878-108X
ISSN:
0166-2236
URN:
uuid:2a5976ed-8a00-4edd-8236-c0020296cfe8
Source identifiers:
185293
Local pid:
pubs:185293

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