Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients.

Journal article

BACKGROUND: The effect of GH replacement on thyroid function in hypopituitary patients has hitherto been studied in small groups of children and adults with conflicting results. OBJECTIVE: We aimed to define the effect and clinical significance of adult GH replacement on thyroid status in a large cohort of GH-deficient patients. PATIENTS AND METHOD: We studied 243 patients with severe GH deficiency due to various hypothalamo-pituitary disorders. Before GH treatment, 159 patients had treated ...

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Authors: Agha, A; Walker, D; Perry, L; Drake, WM; Chew, S

• Publication status: Published
• Journal: Clinical endocrinology
• Volume: 66
• Issue: 1
• Pages: 72-77
• Publication date: 2007-01-01
• DOI: 10.1111/j.1365-2265.2006.02688.x
• EISSN: 1365-2265
• ISSN: 0300-0664
• Language: English
• Keywords: Hormone Replacement Therapy; Chi-Square Distribution; Female; Adult; Middle Aged; Hypothyroidism; Male; Human Growth Hormone; Statistics, Nonparametric; Aged; Humans; Adolescent; Thyroid Function Tests; Thyroxine; Growth Disorders; Hypopituitarism