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Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?

Abstract:

Staphylococcus aureus bacteraemia remains very difficult to treat, and a large proportion of cases result in potentially lethal metastatic infection. Unpredictable and persistent bacteraemia in the face of highly active, usually bactericidal antibiotics is the strongest predictor of death or disseminated disease. Although S. aureus has conventionally been considered an extracellular pathogen, much evidence demonstrates that it can survive intracellularly. In this Opinion article, we propose t...

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Publisher copy:
10.1038/nrmicro2508

Authors


Thwaites, GE More by this author
Journal:
Nature reviews. Microbiology
Volume:
9
Issue:
3
Pages:
215-222
Publication date:
2011-03-05
DOI:
EISSN:
1740-1534
ISSN:
1740-1526
URN:
uuid:2a3c7240-313a-49f8-ab16-f3a713ee1172
Source identifiers:
435222
Local pid:
pubs:435222

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