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Cytomegalovirus e127 protein interacts with the inhibitory CD200 receptor

Abstract:
CD200 is a cell surface glycoprotein that binds an inhibitory receptor (CD200R) on myeloid cells. CD200 orthologues are present in many species of virus, and we show that the rat cytomegalovirus CD200 orthologue (e127) is expressed at the cell surface on infected cells. It binds the host CD200R with the same affinity as that of the host protein, and thus this protein acts as a close mimic of the host protein and has the potential to downregulate immune responses to the virus. © 2011, American Society for Microbiology. All Rights Reserved.

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Publisher copy:
10.1128/JVI.00064-11

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Journal:
Journal of Virology
Volume:
85
Issue:
12
Pages:
6055-6059
Publication date:
2011-06-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:2a35d980-df65-4f1a-b628-ba53f22e6e3d
Source identifiers:
171877
Local pid:
pubs:171877
Language:
English

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