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Matrix-bound growth factors are released upon cartilage compression by an aggrecan-dependent sodium flux that is lost in osteoarthritis

Abstract:

Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints. Here, we describe three pro-regenerative factors; fibroblast growth factor 2 (FGF2), connective tissue growth factor, bound to transforming growth factor-beta (CTGF-TGFβ), and hepatoma-derived growth factor (HDGF), that are rapidly released from the pericellular mat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/function/zqab037

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Role:
Author
ORCID:
0000-0002-2069-544X
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Name:
Arthritis Research UK
Grant:
21621
20205
Publisher:
American Physiological Society
Journal:
Function More from this journal
Volume:
2
Issue:
5
Publication date:
2021-08-02
Acceptance date:
2021-07-30
DOI:
EISSN:
2633-8823
Pmid:
34423304
Language:
English
Keywords:
Pubs id:
1192525
Local pid:
pubs:1192525
Deposit date:
2021-09-02

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