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Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels.

Abstract:

To assess the role of renal innervation in O2-dependent control of erythropoietin (EPO) formation, we have determined EPO mRNA levels in both kidneys of unilaterally denervated rats and sham-operated controls using RNase protection. To investigate whether possible effects of renal nerve input are related to the type of hypoxic stimulus and the degree of stimulation, animals were studied under basal conditions, after exposure to normobaric hypoxia (8% O2, 4 h) or CO (0.1%, 4 h), and after acut...

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Publication status:
Published

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Authors


Eckardt, KU More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Kaissling, B More by this author
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Journal:
The American journal of physiology
Volume:
263
Issue:
5 Pt 2
Pages:
F925-F930
Publication date:
1992-11-05
ISSN:
0002-9513
URN:
uuid:2a30eb0a-9548-4387-bfb8-aa81ac5d0841
Source identifiers:
22208
Local pid:
pubs:22208

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