Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels.

Journal article

To assess the role of renal innervation in O2-dependent control of erythropoietin (EPO) formation, we have determined EPO mRNA levels in both kidneys of unilaterally denervated rats and sham-operated controls using RNase protection. To investigate whether possible effects of renal nerve input are related to the type of hypoxic stimulus and the degree of stimulation, animals were studied under basal conditions, after exposure to normobaric hypoxia (8% O2, 4 h) or CO (0.1%, 4 h), and after acut...

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Authors: Eckardt, K; LeHir, M; Tan, C; Ratcliffe, P; Kaissling, B

• Publication status: Published
• Journal: American journal of physiology
• Volume: 263
• Issue: 5 Pt 2
• Pages: F925-F930
• Publication date: 1992-11-01
• ISSN: 0002-9513
• Language: English
• Keywords: Denervation; Carbon Monoxide; RNA, Messenger; Blood Pressure; Rats, Wistar; Histocytochemistry; Radioimmunoassay; Male; Nucleic Acid Hybridization; Cell Hypoxia; Ribonucleases; Rats; Erythropoietin; Oxygen; Hemorrhage; Hematocrit; Animals; Anemia; Osmolar Concentration; Kidney