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Life, activation and death of intrahepatic lymphocytes in chronic hepatitis C.

Abstract:

The healthy liver of adult humans has little or no lymphocyte component and the histological finding of intrahepatic lymphocytes (IHL) is evidence of liver pathology. In a liver injured by chronic hepatitis C, the most common chronic liver disease, most IHL are activated/pro-inflammatory cells, which are particularly enriched for effectors of innate immunity (natural killer (NK), natural T, and other NK-like T cells). IHL do not undergo clonal expansion in the liver but migrate from extrahepa...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
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Journal:
Immunological reviews
Volume:
174
Pages:
77-89
Publication date:
2000-04-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:2a2ba688-165a-49f7-bcf6-671a6be4df8a
Source identifiers:
10344
Local pid:
pubs:10344

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