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Journal article

Visualizing protein-DNA interactions in live bacterial cells using photoactivated single-molecule tracking.

Abstract:

Protein-DNA interactions are at the heart of many fundamental cellular processes. For example, DNA replication, transcription, repair, and chromosome organization are governed by DNA-binding proteins that recognize specific DNA structures or sequences. In vitro experiments have helped to generate detailed models for the function of many types of DNA-binding proteins, yet, the exact mechanisms of these processes and their organization in the complex environment of the living cell remain far le...

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Publisher copy:
10.3791/51177

Authors


Sherratt, DJ More by this author
Kapanidis, AN More by this author
Journal:
Journal of visualized experiments : JoVE
Issue:
85
Publication date:
2014
DOI:
EISSN:
1940-087X
URN:
uuid:2a24e103-abb1-41c5-8bd1-9639729c8cc9
Source identifiers:
457647
Local pid:
pubs:457647

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