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A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.

Abstract:

Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to define the transcriptional program underlying angiogenesis in human cancer. This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling. Extensive analysis of multiple cancer types demonstrates significant upregulation of ELTD1 in t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ccr.2013.06.004

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology, Anatomy and Genetics
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Weatherall Institute
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Funding agency for:
Banham, AH
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Funding agency for:
Harris, AL
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Funding agency for:
Buffa, FM
National Institutes of Health More from this funder
Department of Defense More from this funder
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Publisher:
Elsevier B.V. Publisher's website
Journal:
Cancer cell Journal website
Volume:
24
Issue:
2
Pages:
229-241
Publication date:
2013-08-05
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:2a24724e-613e-44ba-9709-37254b413c73
Source identifiers:
414442
Local pid:
pubs:414442

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