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Journal article

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.

Abstract:

Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to define the transcriptional program underlying angiogenesis in human cancer. This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling. Extensive analysis of multiple cancer types demonstrates significant upregulation of ELTD1 in t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ccr.2013.06.004

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More from this funder
Name:
Cancer Research UK
Funding agency for:
Banham, A
Harris, A
Grant:
A10702
A10702
More from this funder
Name:
European Union
Funding agency for:
Buffa, F
Publisher:
Elsevier
Journal:
Cancer cell More from this journal
Volume:
24
Issue:
2
Pages:
229-241
Publication date:
2013-08-01
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
Language:
English
Keywords:
UUID:
uuid:2a24724e-613e-44ba-9709-37254b413c73
Local pid:
pubs:414442
Source identifiers:
414442
Deposit date:
2013-11-17

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