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p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65.

Abstract:

The stress-activated c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein (MAP) kinase (p38) regulate apoptosis induced by several forms of cellular insults. Potential targets for these kinases include members of the Bcl-2 family proteins, which mediate apoptosis generated through the mitochondria-initiated, intrinsic cell death pathway. Indeed, the activities of several Bcl-2 family proteins, both pro- and anti-apoptotic, are controlled by JNK phosphorylation. For example,...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m512627200

Authors


Becker, EB More by this author
Journal:
The Journal of biological chemistry
Volume:
281
Issue:
35
Pages:
25215-25222
Publication date:
2006-09-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:2a069ad3-056f-4a84-a3b9-11c4dc04e5b0
Source identifiers:
248010
Local pid:
pubs:248010

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