Atherosclerosis is initiated by the retention of lipoproteins on proteoglycans in the arterial intima. However, the mechanisms leading to proteoglycan accumulation and lipoprotein retention are poorly understood. In this study, we set out to investigate the role of ADAMTS-5 (a disintegrin and metalloprotease with thrombospondin motifs-5) in the vasculature. ADAMTS-5 was markedly reduced in atherosclerotic aortas of apolipoprotein E-null (apoE(-/-)) mice. The reduction of ADAMTS-5 was accompan...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis.
If you are the owner of this record, you can report an update to it here: Report update to this record