Journal article icon

Journal article

[18F]FE-OTS964: A small molecule targeting TOPK for in vivo PET imaging in a glioblastoma xenograft model

Abstract:
Purpose Lymphokine-activated killer T cell-originated protein kinase (TOPK) is a fairly new cancer biomarker with great potential for clinical applications. The labeling of a TOPK inhibitor with F-18 can be exploited for positron emission tomography (PET) imaging allowing more accurate patient identification, stratification, and disease monitoring. Procedures [18F]FE-OTS964 was produced starting from OTS964, a preclinical drug which specifically binds to TOP... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1007/s11307-018-1288-6

Authors


More by this author
Role:
Author
ORCID:
0000-0002-2326-9120
More from this funder
Name:
National Institutes of Health
Grant:
P30 CA008748
Publisher:
Springer Nature
Journal:
Molecular Imaging and Biology More from this journal
Volume:
21
Issue:
4
Pages:
705–712
Publication date:
2018-10-24
DOI:
EISSN:
1860-2002
ISSN:
1536-1632
Pmid:
30357568
Language:
English
Keywords:
Pubs id:
pubs:936537
UUID:
uuid:29e9bfe4-8957-49d8-b317-94da9794fe36
Local pid:
pubs:936537
Source identifiers:
936537
Deposit date:
2018-11-14

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP