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The host protein reticulon 3.1A is utilized by flaviviruses to facilitate membrane remodelling

Abstract:

Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and host factors facilitating viral replication. In this study, we identified a key role for the membrane-bending host protein Reticulon 3.1 (RTN3.1A) during the replication cycle of three flaviviruses: West Nile virus (WNV), Dengue virus (DENV), and Zika virus (ZIKV). We observed that, during infection, RTN3.1A is redistributed and recruited to the viral replication c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.celrep.2017.10.055

Authors


Aktepe, TE More by this author
Liebscher, S More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
ORCID:
0000-0002-9039-7392
Mackenzie, JM More by this author
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
21
Issue:
6
Pages:
1639-1654
Publication date:
2018-11-07
Acceptance date:
2017-10-12
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:926850
URN:
uri:29e3cc98-d288-40b5-9f45-4c452ede3e8f
UUID:
uuid:29e3cc98-d288-40b5-9f45-4c452ede3e8f
Local pid:
pubs:926850

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