Complex dynamic of dengue virus serotypes 2 and 3 in Cambodia following series of climate disasters

Journal article

The Dengue National Control Program was established in Cambodia in 2000 and has reported between 10,000 and 40,000 dengue cases per year with a case fatality rate ranging from 0.7 to 1.7. In this study 39 DENV-2 and 57 DENV-3 viruses isolated from patients between 2000 and 2008 were fully sequenced. Five DENV2 and four DENV3 distinct lineages with different dynamics were identified. Each lineage was characterized by the presence of specific mutations with no evidence of recombination. In both...

Expand abstract

Authors: Duong, V; Henn, M; Simmons, C; Ngan, C; Y, B

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Infection, Genetics and Evolution
• Volume: 15
• Pages: 77-86
• Publication date: 2012-06-04
• DOI: 10.1016/j.meegid.2012.05.012
• EISSN: 1567-7257
• ISSN: 1567-1348
• Pmid: 22677620
• Language: English
• Keywords: Phylogeny; Base Sequence; SBTMR; Cambodia; Middle Aged; Child; Young Adult; Dengue Virus; Journal Article; Humans; Adult; Genome, Viral; Serotyping; Mutation; Disasters; Molecular Sequence Data; Polymorphism, Genetic; Selection, Genetic; Dengue; Genes, Viral; Infant; Climate; Adolescent; Aged; Child, Preschool; Research Support, Non-U.S. Gov't; Open Reading Frames; Amino Acid Sequence