Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes. (Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 2001)

(untitled) - Tamura, T; Kosaka, N; Ishiwa, J; Sato, T; Nagase, H; Ito, A