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Microsatellite genotyping and genome-wide single nucleotide polymorphism-based indices of Plasmodium falciparum diversity within clinical infections

Abstract:

BACKGROUND:In regions where malaria is endemic, individuals are often infected with multiple distinct parasite genotypes, a situation that may impact on evolution of parasite virulence and drug resistance. Most approaches to studying genotypic diversity have involved analysis of a modest number of polymorphic loci, although whole genome sequencing enables a broader characterisation of samples. METHODS:PCR-based microsatellite typing of a panel of ten loci was performed on Plasmodium falciparu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-016-1324-4

Authors


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Role:
Author
ORCID:
0000-0001-9359-4888
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Oxford college:
St John's College
Role:
Author
ORCID:
0000-0002-5023-0176
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Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal
Volume:
15
Article number:
275
Publication date:
2016-05-12
Acceptance date:
2016-05-03
DOI:
EISSN:
1475-2875
Pmid:
27176827
Source identifiers:
1037112
Language:
English
Keywords:
Pubs id:
pubs:1037112
UUID:
uuid:29d4b4ba-90b2-4ce9-9f3d-039c56e2a64d
Local pid:
pubs:1037112
Deposit date:
2019-09-06

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