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Journal article

HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01.

Abstract:

HLA-B*57 is strongly associated with immune control of HIV and delayed AIDS progression. The closely related, but less protective, HLA-B*58:01 presents similar epitopes, but HLA-B*58:01(+) individuals do not generate CD8(+) T cells targeting the KF11-Gag epitope, which has been linked to low viremia. Here we show that HLA-B*58:01 binds and presents KF11 peptide, but HIV-infected HLA-B*58:01(+) cells fail to process KF11. This unexpected finding demonstrates that immunodominance patterns can b...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.01122-13

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Journal:
Journal of virology
Volume:
87
Issue:
19
Pages:
10889-10894
Publication date:
2013-10-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:29d25691-1c08-4586-b11c-ed4456a6d8a5
Source identifiers:
414417
Local pid:
pubs:414417

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