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Journal article

Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.

Abstract:

Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito's innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where ...

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Publication status:
Published

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Publisher copy:
10.1126/science.1177531

Authors


Journal:
Science (New York, N.Y.)
Volume:
326
Issue:
5949
Pages:
134-136
Publication date:
2009-10-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:29cfec38-b4a8-46fc-a7af-e33aabaa1bff
Source identifiers:
163863
Local pid:
pubs:163863

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