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Trials of transvaginal mesh devices for pelvic organ prolapse: a systematic database review of the US FDA approval process.

Abstract:

Transvaginal mesh devices are approved in the USA by the Food and Drug Administration (FDA), through the 510(k) system. However, there is uncertainty about the benefit to harm balance of mesh approved for pelvic organ prolapse. We, therefore, assessed the evidence at the time of approval for transvaginal mesh products and the impact of safety studies the FDA mandated in 2012 because of emerging harms.We used FDA databases to determine the evidence for approval of transvaginal mesh. To create ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/bmjopen-2017-017125

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Oxford college:
Kellogg College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Role:
Author
Publisher:
BMJ Publishing Group
Journal:
BMJ Open More from this journal
Volume:
7
Issue:
12
Pages:
1-9
Publication date:
2017-12-06
Acceptance date:
2017-11-24
DOI:
ISSN:
2044-6055
Pmid:
29212782
Language:
English
Keywords:
Pubs id:
pubs:810861
UUID:
uuid:29ce0b5f-9002-4c39-a8cb-782db6c6fada
Local pid:
pubs:810861
Source identifiers:
810861
Deposit date:
2018-01-17

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