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Single-molecule detection of nitrogen mustards by covalent reaction within a protein nanopore.

Abstract:

Mustards, including sulfur mustards and nitrogen mustards, form a class of cytotoxic, vesicant chemical warfare agents. Mustards have also been used to treat cancer and played a vital role in the development of chemotherapy. Additionally, because of their destructive properties, ease of synthesis, and the lack of effective antidotes, mustards are unquestionably terrorist threats. Therefore, quick and convenient detection of mustards is a critical issue. In the present study, we achieved detec...

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Publication status:
Published

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Publisher copy:
10.1021/ja8004607

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Journal:
Journal of the American Chemical Society
Volume:
130
Issue:
21
Pages:
6813-6819
Publication date:
2008-05-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:29b8b45a-6a50-400d-9729-ccbafb693064
Source identifiers:
52257
Local pid:
pubs:52257

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