Journal article icon

Journal article

Readministration of adenoviral gene delivery to dopamine neurons.

Abstract:

An approach currently being explored as treatment for Parkinson's disease is gene therapy. An important question concerns the duration of transgene expression in dopamine neurons and the issues of vector persistence, neuronal damage and the feasibility of readministering vector to the same neuronal population. We show, using an adenoviral vector expressing the LacZ reporter gene, that transgene expression declined over time but with minimal loss of dopamine neurons or vector DNA. Readministra...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Neuroreport
Volume:
18
Issue:
15
Pages:
1609-1614
Publication date:
2007-10-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:29b78a85-9e2c-495b-be2a-c55c9d43e6ca
Source identifiers:
113957
Local pid:
pubs:113957

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP