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Ejection dynamics of polymeric chains from viral capsids: effect of solvent quality.

Abstract:

We present simulations investigating the effects of solvent quality on the dynamics of flexible (RNA-like) and semiflexible (DNA-like) polymers ejecting from spherical viral capsids. We find that the mean ejection time increases and the ejection time distributions are broadened as the solvent quality decreases. Our results thus suggest that DNA ejection may be very efficiently controlled by tuning the salt concentration in the environment, in agreement with recent experimental findings. We al...

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Publication status:
Published

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Publisher copy:
10.1529/biophysj.107.111963

Authors


Marenduzzo, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
Journal:
Biophysical journal
Volume:
94
Issue:
11
Pages:
4159-4164
Publication date:
2008-06-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:29a9762b-1543-45bf-96e1-ab178c3296c4
Source identifiers:
9955
Local pid:
pubs:9955

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