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Journal article

Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint.

Abstract:

BACKGROUND: Missegregation of chromosomes during meiosis in human females causes aneuploidy, including trisomy 21, and is thought also to be the major cause of age-related infertility. Most errors are thought to occur at the first meiotic division. The high frequency of errors raises questions as to whether the surveillance mechanism known as the spindle assembly checkpoint (SAC) that controls the anaphase-promoting complex or cyclosome (APC/C) operates effectively in oocytes. Experimental ap...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2009.01.064

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Journal:
Current biology : CB
Volume:
19
Issue:
5
Pages:
369-380
Publication date:
2009-03-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:298c8cbc-c950-403a-8d86-7b76be221afc
Source identifiers:
98489
Local pid:
pubs:98489

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