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Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants

Abstract:

The global burden of neonatal and infant mortality due to infection is staggering, particularly in resource-poor settings. Early childhood vaccination is one of the major interventions that can reduce this burden, but there are specific limitations to inducing effective immunity in early life, including impaired neonatal leukocyte production of Th1-polarizing cytokines to many stimuli. Characterizing the ontogeny of Toll-like receptor (TLR)-mediated innate immune responses in infants may shed...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0018185

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Institution:
University of Oxford
Department:
Oxford, MSD, NPEU
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
6
Issue:
4
Pages:
e18185
Publication date:
2011-04-13
Acceptance date:
2011-02-22
DOI:
EISSN:
1932-6203
URN:
uuid:2986b3b8-b70c-42db-b633-c308fb525433
Source identifiers:
236808
Local pid:
pubs:236808
Language:
English
Keywords:

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