Journal article icon

Journal article

Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants

Abstract:

The global burden of neonatal and infant mortality due to infection is staggering, particularly in resource-poor settings. Early childhood vaccination is one of the major interventions that can reduce this burden, but there are specific limitations to inducing effective immunity in early life, including impaired neonatal leukocyte production of Th1-polarizing cytokines to many stimuli. Characterizing the ontogeny of Toll-like receptor (TLR)-mediated innate immune responses in infants may shed...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0018185

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
NPEU
Role:
Author
Expand authors...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
6
Issue:
4
Pages:
e18185
Publication date:
2011-04-13
Acceptance date:
2011-02-22
DOI:
EISSN:
1932-6203
Source identifiers:
236808
Language:
English
Keywords:
UUID:
uuid:2986b3b8-b70c-42db-b633-c308fb525433
Local pid:
pubs:236808
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP