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Journal article

A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity.

Abstract:

BACKGROUND: Despite the availability of efficacious drugs, the success of treating hypertension is limited by patients' inconsistent drug intake. Immunization against angiotensin II may offer a valuable alternative to conventional drugs for the treatment of hypertension, because vaccines induce relatively long-lasting effects and do not require daily dosing. Here we describe the preclinical development and the phase I clinical trial testing of a virus-like particle (VLP)-based antihypertensi...

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Publication status:
Published

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Authors


Ambühl, PM More by this author
Tissot, AC More by this author
Fulurija, A More by this author
Nussberger, J More by this author
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Journal:
Journal of hypertension
Volume:
25
Issue:
1
Pages:
63-72
Publication date:
2007-01-05
DOI:
EISSN:
1473-5598
ISSN:
0263-6352
URN:
uuid:297eaae7-28ba-46c4-a7b4-3203f0e36130
Source identifiers:
469721
Local pid:
pubs:469721

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