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SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.

Abstract:

Programmed death-1 (PD-1) is a critical mediator of virus-specific CD8+ T-cell exhaustion. Here, we examined the expression of PD-1 on simian immunodeficiency virus (SIV)-specific CD8+ T cells and its possible involvement in regulation of cytokine production, proliferation, and survival of these cells. The majority of SIV-specific CD8+ T cells expressed a PD-1(high) phenotype, independent of their differentiation status, in all tissues tested. PD-1 expression gradually declined on CD8+ T cell...

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Publication status:
Published

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Journal:
Blood
Volume:
110
Issue:
3
Pages:
928-936
Publication date:
2007-08-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:297b9bf3-826f-442e-b1ac-10483e6a5b63
Source identifiers:
12927
Local pid:
pubs:12927

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