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The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism.

Abstract:

The African trypanosome, Trypanosoma brucei, causes sleeping sickness in humans in sub-Saharan Africa. Here we report the sequence and analysis of the 1.1 Mb chromosome I, which encodes approximately 400 predicted genes organised into directional clusters, of which more than 100 are located in the largest cluster of 250 kb. A 160-kb region consists primarily of three gene families of unknown function, one of which contains a hotspot for retroelement insertion. We also identify five novel gene...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkg674

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Journal:
Nucleic acids research
Volume:
31
Issue:
16
Pages:
4864-4873
Publication date:
2003-08-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:2977da64-c9d0-4270-8d83-1ca49e04c702
Source identifiers:
30489
Local pid:
pubs:30489

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