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Avirulent strains of Toxoplasma gondii infect macrophages by active invasion from the phagosome.

Abstract:

Unlike most intracellular pathogens that gain access into host cells through endocytic pathways, Toxoplasma gondii initiates infection at the cell surface by active penetration through a moving junction and subsequent formation of a parasitophorous vacuole. Here, we describe a noncanonical pathway for T. gondii infection of macrophages, in which parasites are initially internalized through phagocytosis, and then actively invade from within a phagosomal compartment to form a parasitophorous va...

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Publisher copy:
10.1073/pnas.1316841111
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
111
Issue:
17
Pages:
6437-6442
Publication date:
2014-04-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:465431
UUID:
uuid:296ceeab-272b-4055-b35d-7c3fb9b06a0c
Local pid:
pubs:465431
Source identifiers:
465431
Deposit date:
2014-08-29

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